I thought a CF Card with a size of 4 GB is the sweet spot for using in MS-DOS environment. MS-DOS 6.22 supports the maximum partition size of 2 GB.
I use this CF Card in my Commodore Amiga 2000 with A2386SX BridgeBoard connected to an ISA HDD Controller.
Here you can see the 4 GB CF Card in the Bracket solution:
